Vincristine-induced autonomic neuropathy.

Vincristine-induced autonomic neuropathy.

Neurological adverse effects are known to complicate vincristine treatment. In occasional reports of bowel and bladder disturbance it has not been possible to incriminate autonomic neuropathy. We report here three patients with symptoms and signs which could be ascribed to vincristine-induced autonomic neuropathy. Case Reports Case 1.-A 75-year-old man presented with recurrent Hodgkin's disease...

vincristine-induced cranial neuropathy

how to cite this article: talebian a, goudarzi rm, mohammadzadeh m , mirzadeh as. vincristine-induced cranial neuropathy. iran j child neurol. 2014 winter; 8(1):66-68.   abstract vincristine (vcr) is a vinca alkaloid that is used for treatment of many malignancies. the vinca alkaloids are neurotoxic, usually causing a peripheral neuropathy, but cranial neuropathies are rare as side effects.  de...

Vincristine induced cranial neuropathy.

Neuropathy is a well known side effect of vincristine, however cranial nerve toxicities are reported less frequently which can involve any cranial nerve in mostly bilateral pattern. As many patients have primary tumors or metastatic lesions in sites that could cause the clinician to overlook this reversible cause of neurologic dysfunction, the potential for misdiagnosis is high. Here, along wit...

Vincristine-Induced Cranial Neuropathy

Vincristine (VCR) is a vinca alkaloid that is used for treatment of many malignancies. The vinca alkaloids are neurotoxic, usually causing a peripheral neuropathy, but cranial neuropathies are rare as side effects. Described here is the case of a 2.5-year-old boy, a known case of Wilms' tumor, treated by vincristine (0.067 mg/kg/day) and dactinomycin (0.045 mg/kg/day) after surgery. Three weeks...

Biomarkers for Vincristine-induced Neuropathy